How it Works - NexGard Chewables

Merial, the makers of Frontline Plus, has developed a new molecule—afoxolaner—designed specifically to kill fleas and ticks in dogs. Presented in a soft chew formulated to taste like braised beef, NexGard Chewables are given orally and provide month-long protection. Nexgard chewables are available through prescription only from a veternarian.

Merial says that when ticks and fleas encounter afoxolaner in the dog’s system, the chemical disrupts the parasite’s central nervous system, causing hyperexcitation and death. They have actually seen fleas come to the surface of the dog’s fur and jump around as they are killed.

Afoxolaner is approved to prevent flea infestations by killing fleas before they can lay eggs and continuing to kill new fleas throughout the month. Merial has submitted to the U.S. Food and Drug Administration research on how the active ingredient afoxolander affect ticks. The American dog tick species, D. variabilis, killed by NexGard chewables, can transmit the organisms responsible for Rocky Mountain spotted fever (Rickettsia rickettsii), tularemia (Francella tularensis) and cytauxzoonosis (Cytauxzoon felis). According to parasitologist Michael Dryden, DVM, PhD. Dermacentor the American dog tick species can also cause tick paralysis.

NexGard chewables were approved by the FDA in 2013. According to the Merial, NexGard has demonstrated excellent efficacy at a low dose and is the first and only soft beef-flavored chew approved to kill both fleas and ticks. It is the first flea and tick killer in a delicious, soft chew that dogs love.

In Merial’s research, they found that 90 percent of dogs readily accepted the chew. The braised beef flavored chew will make it easier to administer and improve compliance. Even though it has a beef flavor, it is actually meatless and all vegetable-based. This meatless formula will be able to be given to dogs that have beef allergies. Nexgard chewables can also be administered without food, making it even easier to give your dog.

Merial has even conducted field studies on NexGard chewables and other medications and no serious adverse reactions were observed. It is approved for use in dogs and puppies over 8 weeks of age and weighing at least 4 pounds. It will be available in four sizes for oral administration to dogs and puppies according to weight.

Click here to view the NexGard chewables Product label


NexGard Chewables Quick Facts:


Adverse effects

What side effects may be seen when taking NexGard?
May see vomiting, dry/flaky skin, diarrhea, lethargy or lack of appetite. Consult your veterinarian if you notice any of the above side effects. If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.
Who can take NexGard chewables?
NexGard chewables are only for dogs. Its safety in pregnant, breeding or lactating dogs has not been evaluated, and veterinarians are advised to use with caution in dogs with a history of seizures.
What should I do if I know of or suspect there has been an overdose?
If you know or suspect your pet has had an overdose, or if you observe any of the side effects in your pet, contact your veterinarian immediately.
Are there any know drug interactions?
There are no known contraindications for the use of NexGard. As with any medication, notify your veterinarian of any other medications, including vitamins and supplements your pet is taking while your pet is receiving NexGard chewables.